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Energy Expenditure Preclinical work in rodent models has reported elevations in resting energy expenditure attributed to the glucagon receptor component, distinguishing retatrutide from GLP-1 monotherapy in mechanistic dissection studies
This side effect did not persist by day 28 of the trial, and the authors said there was no significant difference in the heart rate or blood pressure between the groups
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Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
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